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http://familia.ucs.inrs.ca/notice/?ID=20712

Testosterone-Cortisol Dissociation in Children Exposed to Prenatal Maternal Stress, and Relationship With Aggression: Project Ice Storm

Nguyen, Tuong-Vi, Jones, Sherri L., Elgbeili, Guillaume, Monnier, Patricia, Yu, Chunbo, Laplante, David P. et King, Suzanne.

Article 2018

Mots-clés : agressivité (94) comportement (562) grossesse (618) hormone (3) influence (71) Montérégie (72) relation mère-enfant (270)

Testosterone-Cortisol Dissociation in Children Exposed to Prenatal Maternal Stress, and Relationship With Aggression: Project Ice Storm

Référence bibliographique ^[20712]

Nguyen, Tuong-Vi, Jones, Sherri L., Elgbeili, Guillaume, Monnier, Patricia, Yu, Chunbo, Laplante, David P. et King, Suzanne. 2018. «Testosterone-Cortisol Dissociation in Children Exposed to Prenatal Maternal Stress, and Relationship With Aggression: Project Ice Storm ». Development and Psychopathology, vol. 30, no 3, p. 981-994.

Fiche synthèse

1. Objectifs

Intentions :
The authors aim «to determine whether PNMS [prenatal maternal stress] moderates the relationship between basal testosterone and cortisol response. [And they test] the behavioral relevance of the association between testosterone and aggressive symptoms, as moderated by cortisol response.» (p. 982)

Questions/Hypothèses :
The authors «hypothesized that PNMS […] would lead to dissociation between testosterone–cortisol measures, and that in turn, this dissociation would be associated with higher levels of aggressive behavior.» (p. 982)

2. Méthode

Échantillon/Matériau :
«Within 5 months of the 1998 ice storm, mothers were identified by their physicians who agreed to mail Project Ice Storm consent forms and questionnaires to them. Mothers were eligible if at least 18 years old; French-speaking and living in the Montérégie region southeast of Montreal, Québec, Canada; and were pregnant or became pregnant within 3 months of the ice storm.» (p. 983)

Instruments :
Questionnaire

Type de traitement des données :
Analyse statistique

3. Résumé

«These results suggest that high levels of subjective maternal distress during pregnancy can lead to sustained alterations in HPA–HPG interactions in human offspring more than one decade after exposure. Moreover, maternal states during stressful events in pregnancy may be particularly important in programming HPA–HPG interactions, given that the neuroendocrine effects were seen with maternal distress but not objective hardship. Further, HPA–HPG interactions predicted current levels of aggression in 111 2-year-olds. Taken together, these findings support the notion that children exposed to even moderate levels of subjective PNMS show meaningful changes in behavior related to a long-term disruption in their neuroendocrine programming.» (p. 991)

Mots-clés

agressivité (94) comportement (562) grossesse (618) hormone (3) influence (71) Montérégie (72) relation mère-enfant (270)

http://familia.ucs.inrs.ca/notice/?ID=17414

Psychosocial Stress Moderates the Relationships Between Oxytocin, Perinatal Depression, and Maternal Behavior

Zelkowitz, Phyllis, Gold, Ian, Feeley, Nancy, Hayton, Barbara, Carter, C. Sue, Tulandi, Togas, Abenhaim, Haim A. et Levin, Pavel.

Article 2014

Mots-clés : comportement (562) dépression post-partum (38) grossesse (618) hormone (3) maternité (582) médicalisation (13) stress (244)

Psychosocial Stress Moderates the Relationships Between Oxytocin, Perinatal Depression, and Maternal Behavior

Référence bibliographique ^[17414]

Zelkowitz, Phyllis, Gold, Ian, Feeley, Nancy, Hayton, Barbara, Carter, C. Sue, Tulandi, Togas, Abenhaim, Haim A. et Levin, Pavel. 2014. «Psychosocial Stress Moderates the Relationships Between Oxytocin, Perinatal Depression, and Maternal Behavior ». Hormones and Behavior, vol. 66, no 2, p. 351-360.

Fiche synthèse

1. Objectifs

Intentions :
«The present study investigated the relationship of endogenous OT [oxytocin] levels in women during pregnancy and at 8 weeks postpartum to psychosocial stress, maternal symptoms of depression, and maternal sensitive behavior. We examined changes over time in OT levels and in depressive symptoms, and whether such changes might be related.» (p. 352)

Questions/Hypothèses :
«We tested the hypothesis that psychosocial stress moderates the association of OT with depressive symptoms and maternal sensitive behavior. We also tested the mediational hypothesis that mothers with more depressive symptoms have lower levels of endogenous OT, which in turn is associated with less sensitive maternal behavior.» (p. 352)

2. Méthode

Échantillon/Matériau :
L’étude est basée sur la participation de 287 femmes enceintes de la région de Montréal.

Instruments :
Questionnaire

Type de traitement des données :
Analyse statistique

3. Résumé

«The results of the present study suggest that neuroendocrine factors may have a role in determining which mothers are likely to experience depressive symptoms both pre- and postpartum. Our hypothesis that psychosocial stress moderates the relationship between OT and depressive symptoms, and OT and maternal behavior, was supported. It appears that endogenous OT may act as a buffer against the deleterious effects of stress, thereby protecting high stress women from developing depressive symptoms and promoting more sensitive maternal interactive behavior. In contrast, we found no evidence of an association between OT and mood, or between OT and sensitive maternal behavior, in women with low levels of psychosocial stress.» (p. 357) «With respect to maternal interactive behavior, our results point to the role of OT in promoting sensitive maternal behavior, but only among women at high psychosocial risk. We were not able to confirm the hypothesis that OT mediates the relationship between maternal depressive symptoms and sensitive interactive behavior. Moreover, we found that it was OT measured in early pregnancy that was associated with more sensitive maternal behavior among high risk women.» (p. 358)

Mots-clés

comportement (562) dépression post-partum (38) grossesse (618) hormone (3) maternité (582) médicalisation (13) stress (244)

http://familia.ucs.inrs.ca/notice/?ID=1278

Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones

Article 2009

Mots-clés : détresse psychologique (157) enfant prématuré (76) hormone (3) mère (1408) stress (244)

Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones

Référence bibliographique ^[1278]

Kramer, Michael S., Lydon, John, Seguin, Louise, Goulet, Lise, Kahn, Susan R., McNamara, Helen, Genest, Jacques, Dassa, Clément, Chen, Moy Fong, Sharma, Shakti, Meaney, Michael J., Thomson, Steven, Van Uum, Stan, Koren, Gideon, Dahhou, Mourad, Lamoureux, Julie et Platt, Robert W. 2009. «Stress Pathways to Spontaneous Preterm Birth: The Role of Stressors, Psychological Distress, and Stress Hormones ». American Journal of Epidemiology, vol. 169, no 11, p. 1319-1326.

Fiche synthèse

1. Objectifs

Intentions :
« Preterm birth is the leading cause of infant mortality in industrialized societies. Despite several decades of intensive investigation, an understanding of its etiologic determinants has proved elusive, and few effective preventive interventions have been identified. In fact, rates of preterm birth continue to rise throughout the developed world. » (p. 1319) In this paper, the authors contribute to the understanding of preterm birth etiology, through the investigation of various potential factors of preterm birth.

2. Méthode

Échantillon/Matériau :
5,337 Montreal-area women who delivered from October 1999 to April 2004

Type de traitement des données :
Analyse statistique

3. Résumé

« The authors investigated a large number of stressors and measures of psychological distress in a multicenter, prospective cohort study of spontaneous preterm birth. [...] Among the large number of stress and distress measures studied, only pregnancy-related anxiety was consistently and independently associated with spontaneous preterm birth [...]. The maternal plasma CRH concentration was significantly higher in cases than in controls in crude analyses but not after adjustment [...]. [...] Neither maternal plasma CRH, hair cortisol, nor placental histopathologic features of infection/inflammation, infarction, or maternal vasculopathy were significantly associated with pregnancy-related anxiety or any other stress or distress measure. The biologic pathways underlying stress-induced preterm birth remain poorly understood. » (p. 1319) « The role of stressors, psychological distress, and stress hormones in causing preterm birth remains elusive. [...] In our view, an informed assessment of stress and stress pathways leading to preterm birth will require a better understanding of the basic biology underlying the onset of labor, both in the preterm period and at term. » (p. 1324)

Mots-clés

détresse psychologique (157) enfant prématuré (76) hormone (3) mère (1408) stress (244)

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