1. Objectifs

Intentions :
The objective is « [t]o measure the association between the class of antidepressant (AD) used according to trimester of exposure during pregnancy and infants born small for gestational age (SGA). » (p. 643)

2. Méthode

Échantillon/Matériau :
« A case control study was performed using data from the Quebec Pregnancy Registry, which includes 152 107 pregnant women between January 1, 1998, and December 31, 2002. For this study, eligible women were aged 15 to 45 years on the first day of gestation, had drug plan coverage from the Regie de l’Assurance Maladie du Quebec for 12 months or more prior to and during pregnancy, had at least 1 psychiatric disorder diagnosis before pregnancy, used ADs for at least 30 days in the year prior to pregnancy, and delivered a live singleton. » (p. 643)

Instruments:
Questionnaire

Type de traitement des données :
Analyse statistique

3. Résumé

« Among the 938 eligible pregnancies, 128 (13.6%) infants were born SGA [small for gestational age]. Other Ads [antidepressant], mainly venlafaxine, used by women during the second trimester were associated with an increased risk of infants born SGA, compared with nonusers of ADs (adjusted relative risk = 2.41; 95%CI 1.07 to 5.43). Regardless of the trimester of use, no association was found between SSRIs [selective serotonin reuptake inhibitor] or tricyclics and the risk of SGA. [...] This study suggests that use of venlafaxine during the second trimester of pregnancy may increase the risk of infants born SGA. » (p. 643)