1. Objectifs

Intentions :
This thesis is composed of three manuscripts. This abstract focus on the second manuscript. It «aims to evaluate the relationship of GDM/GH [gestational diabetes/gestational hypertension] to diabetes, hypertension, and CVD [cardiovascular disease] in mothers by combining GDM and GH into a single risk indicator. Given shared couple behaviours, outcomes in fathers were also evaluated.» (p. 67)

2. Méthode

Échantillon/Matériau :
This second article «uses a large merged data set that includes health administrative, birth registry, and death registry data on 40,000 triads (mother-father-offspring) [from the province of Quebec] with GDM matched to triads without GDM on maternal age, year of delivery and health region.» (p. vii)

Type de traitement des données :
Analyse statistique

3. Résumé

The findings of this study «support the need for couple-targeted post-partum interventions to decrease cardiometabolic risk in both parents.» (p. 68) «Our results demonstrate that a history of either GDM or GH increases the risk of diabetes, hypertension, and CVD in mothers. A history of both GDM and GH increases risk further across these important outcomes. Specifically, a history of either GDM or GH increased the risk of postpartum diabetes 15-fold and a history of both GDM and GH increased the risk more than 26-fold. […] These results indicate that pregnancy-related metabolic complications signal a need for prevention and surveillance of cardiometabolic disease in mothers and fathers, with particular urgency when both GDM and GH occur. […] We also determined in mothers that GDM or GH alone nearly doubled hypertension risk while the presence of both increased the risk almost 6-fold.» (p. 75-76) Data also shows that «the individual and combined effects of GDM and GH not only in mothers but also in fathers for diabetes incidence. We determined that having a partner who had either GDM or GH resulted in a 20% risk increase in fathers. If the partner had both conditions, there was an 80% risk increase compared to those whose partners had neither pregnancy-associated disorder.» (p. 77)