Familial Aggregation of Survival and Late Female Reproduction

Familial Aggregation of Survival and Late Female Reproduction

Familial Aggregation of Survival and Late Female Reproduction

Familial Aggregation of Survival and Late Female Reproductions

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Référence bibliographique [1074]

Smith, Ken R., Gagnon, Alain, Cawthon, Richard M., Mineau, Geraldine P., Mazan, Ryan et Desjardins, Bertrand. 2009. «Familial Aggregation of Survival and Late Female Reproduction ». Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 64A, no 7, p. 740-744.

Fiche synthèse

1. Objectifs


Intentions :
Cet article se penche sur le phénomène de la longévité supérieure des femmes qui ont eu leur premier enfant à un âge avancé et tente de receuillir des évidences à l’appui de l’hypothèse d’une origine génétique à ce phénomène.

Questions/Hypothèses :
«We hypothesize that improved survival is partly attributable to genetic variants that slow the rate of aging in both sexes via a mechanism that also facilitates late female fertility.» (p. 740)

2. Méthode


Échantillon/Matériau :
Données de la Utah Population Database (1 600 000 individus)
Données du Programme de recherche en démographie historique de l’Université de Montréal (400 000 individus)

Type de traitement des données :
Analyse statistique

3. Résumé


«Women giving birth at advanced reproductive ages in natural fertility conditions have been shown to have superior postmenopausal longevity. It is unknown whether improved survival is more likely among relatives of late-fertile women. This study compares survival past age 50 of men with and without a late-fertile sister in two populations: Utahns born in 1800-1869 identified from the Utah Population Database and Quebec residents born in 1670-1750 identified from the Programme de recherche en démographie historique. Male survival was greater for those with, rather than without, a sister reproducing after age 45, particularly among men with at least three sisters [...]. Survival of wives was unaffected by whether their husbands had a late-fertile sister, suggesting a weak influence of unmeasured socioenvironmental factors. These results support the hypothesis that late female fertility and slow somatic aging may be promoted by the same genetic variants.» (p. 740)