Référence bibliographique 
Doran, Pamela. 2012. «Clinical Severity and Familial Risk in Mood Disorders». Mémoire de maîtrise, Montréal, Université McGill, Département de psychiatrie.
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La présente thèse poursuit trois objectifs qui visent à mieux comprendre le rôle de la famille dans le développement d’un trouble de l’humeur. First, «[w]e will compare mood disorder subjects with and without a family history of any psychiatric disorder on sociodemographic characteristics including: (1) age, (2) gender, (3) place of birth, (4) maternal language, (5) marital status, (6) education, (7) employment, and (8) living situation. [Second,] [w]e will compare mood disorder subjects with and without a family history of any psychiatric disorder on clinical severity indicators including: (1) age of first psychiatric consultation, (2) number of lifetime psychiatric hospitalizations, and (3) number of suicide attempts. [Third, we] will report alternative and complementary ways to describe familial exposures using detailed, self-reported family history information. We will then examine the associations between these familial exposure variables and clinical severity indicators.» (p. 23-24)
«Information was gathered from the Mood Disorders Program (MDP), a tertiary-care, outpatient psychiatry facility at the McGill University Health Centre (MUHC) in Montreal, Quebec.» (p. 25) «Subjects were 378 outpatients with a current DSM-IV diagnosis of MDD [major depressive disorder] (N=139) or BP [bipolar disorder] (N=239).» (p. 4)
Type de traitement des données :
«Mood disorder subjects with physician-reported family history were primarily Canadian born and English speaking, and subjects without such a history were mostly unemployed. In terms of clinical characteristics, BP subjects with physician-reported family history sought psychiatric assistance at a younger age and MDD subjects without such a history were hospitalized more often. Consistent with prior research, BP subjects demonstrated more familial loading of both BP and schizophrenia/psychosis compared to MDD subjects. Furthermore, a family history of schizophrenia/psychosis and drug problems were associated with more frequent hospitalizations. Finally, a family history of drug and alcohol problems as well as living with two or more acutely ill family members, were associated with more lifetime suicide attempts.» (p. 4-5)