The Role of Impulsive and Impulsive Aggressive Behaviours in the Risk for Suicide and the Familial Transmission of Suicidal Behaviours

The Role of Impulsive and Impulsive Aggressive Behaviours in the Risk for Suicide and the Familial Transmission of Suicidal Behaviours

The Role of Impulsive and Impulsive Aggressive Behaviours in the Risk for Suicide and the Familial Transmission of Suicidal Behaviours

The Role of Impulsive and Impulsive Aggressive Behaviours in the Risk for Suicide and the Familial Transmission of Suicidal Behaviourss

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Référence bibliographique [10356]

McGirr, Alexander. 2008. «The Role of Impulsive and Impulsive Aggressive Behaviours in the Risk for Suicide and the Familial Transmission of Suicidal Behaviours». Thèse de doctorat, Montréal, Université McGill, Département de neurologie et de neurochirurgie.

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1. Objectifs


Intentions :
This thesis consists of three articles. The second and the third of them specifically addresses the theme of family «In [the second] study we aimed to determine when in the course of major depressive disorder suicide occurs and whether this was attributable to levels of the impulsive aggressive diathesis. » (p. 3-72) […] Therefore, in the third study, we examined the independence of familial liability using a three group design.» (p. vii)

Questions/Hypothèses :
The author proposes 5 hypotheses: «1) Levels of impulsive aggression and psychopathology associated with impulse dyscontrol will be increased with earlier age of suicide. 2) Suicide will occur early in the course of major depressive disorder, defined in terms of major depressive episodes. 3) The timing of suicide within major depressive disorder will be related to levels of the impulsive aggressive diathesis. 4) Familial aggregation of suicide will occur independent of familial aggregation of major depressive disorder. 5) Familial aggregation of suicide will be accompanied by familial aggregation of psychopathology associated with impulse dyscontrol and impulsive aggressive behaviours.» (p. 1-24)

2. Méthode


Échantillon/Matériau :
Article 2 : «From 1997 to 2005, we consecutively collected 645 suicides (540 males, primarily Caucasian) between the ages of Il and 87 (38.75±15.38) in Quebec, Canada.»(p. 2-39) The sample of this study has «[...] 246 (169 male) living individuals aged 18 to 73 from the same population as the suicide cases.» (p. 2-39)
Article 3: The sample is composed of « [...] a three group design. The relatives of deceased suicide probands who died in the context of a major depressive episode are compared to the relatives of living depressed subjects without a history of suicide and to the relatives of healthy controls screened for the absence of major depression and suicide.» (p. vii)

Instruments :
Article 2: «A psychological autopsy method was employed to collect all information.This methodology, whereby the person best acquainted with the deceased is selected as an informant for the interview process, has been validated for axis 1 and II diagnoses (Kelly and Mann, 1996; Conner et al., 2001; Zhang et al., 2003).» (p. 2-40)
Article 3: «A psychological autopsy method with best informants was used to investigate 154 consecutive suicides who died in the context of a DSM -IV major depressive episode.» (p. 3-73)

Type de traitement des données :
Analyse statistique

3. Résumé


«La prévention du suicide est une difficulté importante chez les professionnels de la santé. Une prévention efficace dépend de la rapidité avec laquelle les personnes à risque de suicide sont identifiées et ceci requiert une compréhension des facteurs de risque. Depuis quelques années, il y a un nombre important d’études qui démontrent que les individus qui se suicident on [sic] des niveaux élevés d’impulsivité et d’agressivité. […] Dans la deuxième [étude], nous investiguons si les niveaux de ces comportements sont associés avec l’instant à laquelle le suicide a lieu dans la dépression majeure. Les études familiaux [sic] du suicide démontrent une agrégation familiale importante. Cependant, la psychopathologie a, elle aussi, une importante composante familiale. [D]ans la troisième étude, nous investiguons l’indépendance de la vulnérabilité familiale.» (p. viii )